| Autor: |
Anissa Bey, PhD, Jiasen Ma, PhD, Keith M. Furutani, PhD, Michael G. Herman, PhD, Jedediah E. Johnson, PhD, Robert L. Foote, MD, Chris J. Beltran, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Particle Therapy, Vol 8, Iss 4, Pp 25-36 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2331-5180 |
| DOI: |
10.14338/IJPT-20-00040.1 |
| Popis: |
Purpose: This article presents an in vivo imaging technique based on nuclear fragmentation of carbon ions in irradiated tissues for potential real-time monitoring of carbon-ion radiation therapy (CIRT) treatment delivery and quality assurance purposes in clinical settings. Materials and Methods: A proof-of-concept imaging and monitoring system (IMS) was devised to implement the technique. Monte Carlo simulations were performed for a prospective pencil-beam scanning CIRT nozzle. The development IMS benchmark considered a 5×5-cm2 pixelated charged-particle detector stack positioned downstream from a target phantom and list-mode data acquisition. The abundance and production origins, that is, vertices, of the detected fragments were studied. Fragment trajectories were approximated by straight lines and a beam back-projection algorithm was built to reconstruct the vertices. The spatial distribution of the vertices was then used to determine plan relevant markers. Results: The IMS technique was applied for a simulated CIRT case, a primary brain tumor. Four treatment plan monitoring markers were conclusively recovered: a depth dose distribution correlated profile, ion beam range, treatment target boundaries, and the beam spot position. Promising millimeter-scale (3-mm, ≤ 10% uncertainty) beam range and submillimeter (≤0.6-mm precision for shifts |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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