Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia

Autor: Ameen Abdulaziz Basabaeen, Enaam Abdelrhman Abdelgader, Othman Saeed BaHashwan, Ebtihal Ahmed Babekir, Nour Mahmoud Abdelateif, Salem Ahmed Bamusa, Saadia Osman Abdelrahim, Osama Ali Altayeb, Eman Abbass Fadul, Ibrahim Khider Ibrahim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Druh dokumentu: article
ISSN: 1756-0500
DOI: 10.1186/s13104-019-4319-8
Popis: Abstract Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation. Results In the present cross-sectional descriptive study, analysis of ZAP-70 expression showed that 36/110 (32.7%) patients positively expressed ZAP-70 and insignificant higher presentation in intermediate and at advanced stages as well as no correlation was seen with hematological parameters and clinical features compared with negatively ZAP-70, on the other hand, 41/110 (37.3%) were CD38+ and no significant correlation was shown with the stage at presentation, clinical characteristics (except Splenomegaly, P = 0.02) and hematological parameters. However, in combined expressions of both ZAP-70 and CD38 together, 20/110 (18.2%) were concordantly ZAP-70+/CD38+, 53/110 (48.2%) concordantly ZAP-70−/CD38− and 37/110 (33.6%) either ZAP-70+ or CD38+, and these three groups showed insignificant correlation with clinical (except Splenomegaly, P = 0.03) and hematological parameters, and the stage at presentation. Our data showed the combined analysis of these two markers, lead to classify our patients into three subgroups (either concordant positive, negative or discordant expressions) with statistically insignificant correlation with clinical presentation (except Splenomegaly), hematological parameters and stage at presentation of B-CLL patients.
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