Ischemic strokes revealing neurosyphilis: Study of six (6) observations at the neurology Department of the University Hospital of Conakry

Autor: M.L. Touré, T.H. Baldé, M.S. Diallo, G. Carlos Othon, N. Camara, S.D. Barry, M.M. Konaté, F. Sakadi, E. Lamah, B. Diallo, M. Diakité, A. Sakho, D. Camara, S. Condé, H. Madandi, V. Millimono, A.K.T. Barry, M.T. Diallo, N. Traoré, F.D. Kassa, A. Koné, I.S. Souaré, J.M. Kadji, M.H. Diallo, A. Tounkara, S.A. Rafkat, T.M. Diallo, J.F. Mara, F.A. Cissé, A. Cissé
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: eNeurologicalSci, Vol 32, Iss , Pp 100470- (2023)
Druh dokumentu: article
ISSN: 2405-6502
DOI: 10.1016/j.ensci.2023.100470
Popis: Introduction: In sub-Saharan Africa (SSA), stroke is a major public health problem and the etiological aspects are poorly studied and documented because of under-medicalization; the syphilitic etiology is rarely mentioned. Patients and methods: We performed a retrospective study of 472 patients hospitalized for ischemic stroke between 2016 and 2021 in the Neurology Department of the University Hospital of Conakry, confirmed by neuroradiological explorations (brain CT, MRI-Angio) and a biological workup including VDRL-TPHA serological reactions in blood and CSF. Results: Syphilitic etiology was retained for six (6) patients (4 men and 2 women) with a mean age of 43 years (extremes 36 and 49 years). The clinical picture was dominated by carotid syndromes: superficial and deep sylvian syndrome, anterior cerebral artery syndrome and vertebro-basilar syndromes and one case of lacunar syndrome.The diagnosis was based on the positivity of serological reactions (VDRL-TPHA) in blood and cerebrospinal fluid (CSF) and the presence of a predominantly lymphocytic hypercellularity and a hyperproteinorachy in the CSF in the absence of any other etiology. Conclusion: These neurological vascular syndromes consecutive to a cerebral treponematous attack are often the result of a still poorly conducted management of primary and secondary syphilis in our country.
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