Effects of chronic caloric restriction on kidney and heart redox status and antioxidant enzyme activities in Wistar rats
| Autor: | Marcio Ferreira Dutra*, Ivi Juliana Bristot, Cristiane Batassini, Nubia Broetto Cunha, Adriana Fernanda Kuckartz Vizuete, Daniela Fraga de Souza, Jose Cl |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | BMB Reports, Vol 45, Iss 11, Pp 671-676 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1976-6696 1976-670X |
| Popis: | Caloric restriction (CR) has been associated with healthbenefits and these effects have been attributed, in part, tomodulation of oxidative status by CR; however, data are stillcontroversial. Here, we investigate the effects of seventeenweeks of chronic CR on parameters of oxidative damage/modification of proteins and on antioxidant enzyme activitiesin cardiac and kidney tissues. Our results demonstrate that CRinduced an increase in protein carbonylation in the heartwithout changing the content of sulfhydryl groups or theactivities of superoxide dismutase and catalase (CAT).Moreover, CR caused an increase in CAT activity in kidney,without changing other parameters. Protein carbonylation hasbeen associated with oxidative damage and functionalimpairment; however, we cannot exclude the possibility that,under our conditions, this alteration indicates a differentfunctional meaning in the heart tissue. In addition, wereinforce the idea that CR can increase CAT activity in thekidney. |
| Databáze: | Directory of Open Access Journals |
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