Ubiquitin: Not just a one‐way ticket to the proteasome, but a therapeutic dial to fine‐tune the molecular landscape of disease

Autor:	A. Hyun Kim, P. Murdo Chiknas, Robin E. C. Lee
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	deubiquitylating enzyme precision medicine ubiquitin ubiquitin modifying enzymes Medicine (General) R5-920
Zdroj:	Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2001-1326
DOI:	10.1002/ctm2.1769
Popis:	Abstract Recently, there is a rise in studies that recognize the importance of targeting ubiquitin and related molecular machinery in various therapeutic contexts. Here we briefly discuss the history of ubiquitin, its biological roles in protein degradation and beyond, as well as the current state of ubiquitin‐targeting therapeutics across diseases. We conclude that targeting ubiquitin machinery is approaching a renaissance, and tapping its full potential will require embracing a wholistic perspective of ubiquitin's multifaceted roles.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f79c51b17dd14715a4d436fbabfe127b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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