| Autor: |
Eri Sagawa, Hironao Okubo, Hitoshi Ando, Yushi Sorin, Ryo Kanazawa, Eisuke Nakadera, Hiroo Fukada, Shigehiro Kokubu, Akihisa Miyazaki |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 139, Iss 4, Pp 373-376 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2019.01.015 |
| Popis: |
To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight reduction of >1.5 kg/week. Serum albumin levels were significantly lower in responders than in non-responders (P = 0.031). However, the pharmacokinetics varied greatly among individuals and was not relevant to the clinical response. Keywords: Tolvaptan, Pharmacokinetics, Hepatic edema |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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