| Autor: |
Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms15648 |
| Popis: |
Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1, thus functionally supporting interaction with Treg cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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