Early use of tocilizumab in solid organ transplant recipients with COVID‐19: A retrospective cohort study in Saudi Arabia

Autor: Amani H. Yamani, Basem M. Alraddadi, Reem S. Almaghrabi, Afnan A. Amer, Fatimah S. Mehdawi, Mohammed A AL‐Hamzi, Meshari S. Aldajani, Majda S. Alattas, Aiman M. Elsaed Ramadan, Ghassan Y Wali, Abeer N. Alshukairi, Abbas Al Mutair
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 10, Iss 3, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.587
Popis: Abstract Background Tocilizumab was studied to reduce cytokine syndrome in patients with severe COVID‐19 pneumonia in solid organ transplant (SOT) recipients with conflicting results. We aim to study the early use of tocilizumab in SOT with COVID‐19 pneumonia on low flow oxygen. Methods This is a retrospective cohort study that was conducted in two transplant centers in Saudi Arabia among 46 SOT with COVID‐19 comparing 21 patients who received tocilizumab to 25 patients who received standard of care. Their clinical characteristics and outcomes were described. Results Compared to patients who received standard of care, patients in the tocilizumab group were older (60.2 ± 12.8 vs. 48.6 ± 12.3, p = .003), had higher ferritin (862.1 ± 919.1 vs. 414 ± 447.3, p = .025) and C‐reactive protein (CRP) (85 ± 83.1 vs. 42.9 ± 57.3, p = .012). More patients in the tocilizumab group required high flow oxygen (38.1% vs. 8.0%, p = .028) compared to patients on standard of care. There were no differences in mortality or mechanical ventilation requirement. Hospital stay was significantly shorter in the tocilizumab group than the standard of care group (9.6 ± 7.4 vs. 20.7 ± 11.7, p
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