Kaposi′s sarcoma following immunosuppressive therapy for vasculitis

Autor: Tarik Bouattar, Laila Kazmouhi, Zaitouna Alhamany, Kawtar Beqqal, Laila Haffane, Tarik Sqalli Houssaini, Hakima Rhou, Loubna Benamar, Karima Senouci, Rabia Bayahia, Naima Ouzeddoun
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Saudi Journal of Kidney Diseases and Transplantation, Vol 22, Iss 2, Pp 319-323 (2011)
Druh dokumentu: article
ISSN: 1319-2442
Popis: Kaposi′s sarcoma (KS) is widely reported to develop after renal transplantation and is induced by activation of a latent human herpes virus 8. We report the clinical features and outcome of a 50-year-old woman who presented with KS 18 weeks after starting immuno-suppressive therapy for vasculitis. She had positive-titer IgG antibody to human herpes virus 8. Cyclophosphamide pulses were interrupted, and prednisone was decreased gradually to 10 mg/day. Skin lesions showed important regression with stabilization of the general state and renal function. Eight months later, the patient presented with a diffuse cutaneous KS that required the discontinuation of steroids. Within 1 month, her general status and renal function deteriorated, and she died with a disseminated intravascular coagulation syndrome.
Databáze: Directory of Open Access Journals