| Autor: |
Mendiola Jaime, Roca Manuela, Mínguez-Alarcón Lidia, Mira-Escolano Maria-Pilar, López-Espín José J, Barrett Emily S, Swan Shanna H, Torres-Cantero Alberto M |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Environmental Health, Vol 11, Iss 1, p 90 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1476-069X |
| DOI: |
10.1186/1476-069X-11-90 |
| Popis: |
Abstract Background In animals, anogenital distance (AGD) at birth reflects androgen levels during pregnancy and predicts adult AGD. Little is known about AGD in relation to female reproductive characteristics in humans, a question this study was designed to explore. Methods We used multiple linear and logistic regression analyses to model the relationships between adult female reproductive system characteristics (e.g. ovarian morphology, menstrual cycle) and two measures of AGD [anus-fourchette (AGDAF) and anus-clitoris (AGDAC)] in 100 college-age volunteers in Spain. Ovarian morphology was classified as having < 6 or ≥ 6 follicles per ovary. Results Both AGD measures were positively associated with ovarian follicle number, with AGDAF being more strongly associated. Women in the upper tertile of the AGDAF and AGDAC distributions were more likely to have ≥ 6 ovarian follicles [OR: 6.0 (95% CI 2.0, 17.6) and 3.0 (95% CI 1.1, 8.6), respectively] compared to women in the lowest tertile. Conclusions Increased follicular recruitment has been related to excess androgen exposure in utero in toxicological studies. Our results suggest that the androgenic environment during early fetal life may influence reproductive system development, including AGD, in human females. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
