'Suffocating' tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy

Autor:	Bassam Janji, Salem Chouaib
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	hypoxia hypoxia-inducible factor melanoma cold/hot tumors immune landscape nk cells cd8 t-lymphocytes cancer immunotherapy anti-pd-1/pd-l1 chemokines ccl5/rantes Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 10, Iss 1 (2021)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2021.1968611
Popis:	We recently reported that inhibiting Hypoxia-inducible Factor-1α (Hif1a) transcriptional activity improves melanoma immunotherapy by driving immune cells into the tumor microenvironment (TME). This Author’s View provides additional perspectives on how hypoxia inhibitors combined with immunotherapy can be used as innovative approaches to improve the therapeutic benefit of melanoma patients.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f7700974330940fa848f3fdc0c6de04a Zobrazit plný text záznamu View record in DOAJ