Hemorrhagic manifestations of cerebral amyloid angiopathy: from pathogenesis to clinical significance

Autor: A. A. Kulesh, V. E. Drobakha, V. V. Shestakov
Jazyk: ruština
Rok vydání: 2018
Předmět:
Zdroj: Неврология, нейропсихиатрия, психосоматика, Vol 10, Iss 3, Pp 4-11 (2018)
Druh dokumentu: article
ISSN: 2074-2711
2310-1342
45689245
DOI: 10.14412/2074-2711-2018-3-4-11
Popis: The paper characterizes the neuropathological aspects of cerebral amyloid angiopathy (CAA) and its pathogenesis. It presents in detail the current neuroimaging markers of CAA and their neuropathological correlates. The phenotypic heterogeneity of the disease and its main clinical manifestations are considered; the updated Boston diagnostic criteria are formulated. The issues of intracerebral hemorrhages, cerebral microbleeding, and cortical superficial siderosis, which are associated with CAA, are elucidated in detail. CAA is noted to be of clinical significance for the determination of therapeutic policy in hemorrhagic stroke, systemic thrombolytic therapy, and cognitive impairment.
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