| Autor: |
Jian Zhang, Wenhui Li, Zhiwei Ying, Di Zhao, Guofu Yi, He Li, Xinqi Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Food & Nutrition Research, Vol 64, Iss 0, Pp 1-13 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1654-661X |
| DOI: |
10.29219/fnr.v64.3677 |
| Popis: |
Background: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals. Objective: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Design: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized. Results: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation. Conclusions: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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