| Autor: |
Rakhee Mistry, Luke S.P. Moore, Nabeela Mughal, Andrew Godfrey, Stephen Hughes |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Clinical Infection in Practice, Vol 21, Iss , Pp 100341- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1702 |
| DOI: |
10.1016/j.clinpr.2024.100341 |
| Popis: |
Background: Drug-induced immune haemolytic anaemia (DIIHA) is a rare adverse effect which varies between mild to fatal (Garratty, 2010). One of the most common class of drugs reported to cause severe DIIHA are the second and third generation cephalosporins (e.g. ceftriaxone) (Garratty, 2010; Hill et al., 2017).We report an event of severe, life-threatening DIIHA caused by ceftriaxone administered in an ambulatory setting to a patient via Outpatient Parenteral Antimicrobial Therapy (OPAT) service and our subsequent management of the adverse reaction. Case report: A 60-year old male was referred to the OPAT service for radiologically-confirmed osteomyelitis. He was commenced on ceftriaxone 4 g daily intravenous infusions in the ambulatory care unit. Shortly after receiving the ninth dose, he became acutely pale, tachycardic, tachypnoeic, and hypotensive with multiple witnessed syncopal episodes inside the unit. Haemoglobin level fell to |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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