Polymorphism rs143384 GDF5 reduces the risk of knee osteoarthritis development in obese individuals and increases the disease risk in non-obese population

Autor: Vitaly Novakov, Olga Novakova, Maria Churnosova, Inna Aristova, Marina Ponomarenko, Yuliya Reshetnikova, Vladimir Churnosov, Inna Sorokina, Irina Ponomarenko, Olga Efremova, Valentina Orlova, Irina Batlutskaya, Alexey Polonikov, Evgeny Reshetnikov, Mikhail Churnosov
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Arthroplasty, Vol 6, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 2524-7948
DOI: 10.1186/s42836-023-00229-9
Popis: Abstract Background We investigated the effect of obesity on the association of genome-wide associative studies (GWAS)-significant genes with the risk of knee osteoarthritis (KOA). Methods All study participants (n = 1,100) were divided into 2 groups in terms of body mass index (BMI): BMI ≥ 30 (255 KOA patients and 167 controls) and BMI
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