Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies

Autor:	Kavitha Ramaswamy, Mariya Rashid, Selvarajan Ramasamy, Tamilselvan Jayavelu, Sangita Venkataraman
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	replication polymerase cofactors structure RNA viruses inhibitors Microbiology QR1-502
Zdroj:	Viruses, Vol 14, Iss 10, p 2200 (2022)
Druh dokumentu:	article
ISSN:	1999-4915
DOI:	10.3390/v14102200
Popis:	RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f73f9ae8cb0945c78fa2d03a56108ed9 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.