Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

Autor: Marta Lukačišinová, Booshini Fernando, Tobias Bollenbach
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16932-z
Popis: The antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance through epistasis.
Databáze: Directory of Open Access Journals