Correlation of thioredoxin reductase (TrxR) and nitric oxide synthase (NOS) activities with serum trace elements in preeclampsia

Autor: Sahar Mazloomi, Iraj Khodadadi, Shohreh Alimohammadi, Gholamreza Shafiee
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical and Experimental Hypertension, Vol 43, Iss 2, Pp 120-124 (2021)
Druh dokumentu: article
ISSN: 1064-1963
1525-6006
10641963
DOI: 10.1080/10641963.2020.1817476
Popis: Background Preeclampsia is a dangerous disease of pregnancy with symptoms such as high blood pressure and proteinuria. The nitric oxide synthase (NOS) enzyme produces nitric oxide (NO) as a mediator of vasodilation and need to calcium and zinc ions for activity. The thioredoxin reductase (TrxR) as an enzyme containing selenium has been neutralized the damaging effects of oxidants. In this study, our aim was to evaluate the activity of eNOS and TrxR enzymes and the amounts of calcium, zinc, and selenium elements in serum of women with preeclampsia. Material and Methods Thirty preeclampsia and 30 healthy pregnant women were enrolled in the study after clinical examination and confirmation by Obstetrician-Gynecologist. Venous blood samples were collected and the activity of NOS, TrxR enzymes, and the concentration of zinc, calcium, and selenium elements were measured in serum. Results The results of NOS and TrxR activities showed significant decreases in preeclampsia compared with control group (p
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