COVID-19 Outcomes in Lung Transplant Recipients Following Pre-Exposure Prophylaxis With Tixagevimab-Cilgavimab During the Omicron BA.5 Surge: A Single Center Analysis

Autor: Saartje Demolder, Veronique Schaevers, Katrien Lagrou, Paul De Munter, Hanne Beeckmans, Geert M. Verleden, Laurent Godinas, Lieven J. Dupont, Pascal Van Bleyenbergh, Natalie Lorent, Robin Vos
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Transplant International, Vol 37 (2024)
Druh dokumentu: article
ISSN: 1432-2277
DOI: 10.3389/ti.2024.12061
Popis: Lung transplant (LTx) recipients are at high risk for COVID-19 related morbidity and mortality. Data regarding pre-exposure prophylaxis (PrEP) with tixagevimab-cilgavimab in this population are scarce. We therefore evaluated COVID-19 breakthrough infections and COVID-19 related complications after PrEP in a retrospective single-center study, including 264 LTx recipients who received PrEP between June 2022 and December 2022, when Omicron BA.5 was the dominant circulating SARS-CoV-2 variant. PrEP was indicated for fully vaccinated patients with poor seroconversion (anti-S
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