Lessons from Animal Models in Sjögren’s Syndrome

Autor:	Diana Mieliauskaitė, Vilius Kontenis, Almantas Šiaurys
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	animal models genetic mouse model induced mouse model humanized mouse model Sjögren’s syndrome microbiota Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 24, Iss 16, p 12995 (2023)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms241612995
Popis:	Primary Sjögren’s syndrome (pSS) is a connective tissue disease characterized by a wide spectrum of clinical features, extending from a benign glandular disease to an aggressive systemic disorder and/or lymphoma. The pathogenesis of Sjögren’s syndrome (SS) is not completely understood, but it is assumed that pathogenesis of SS is multifactorial. The studies based on the animal models of SS provided significant insight in SS disease pathogenesis and management. The aim of this review is to summarize current studies on animal models with primary SS-like symptoms and discuss the impact of these studies on better understanding pathogenesis and management of Sjögren’s syndrome. Databases PubMed, Web of Science, Scopus and Cochrane library were searched for summarizing studies on animal models in SS. Available data demonstrate that animal models are highly important for our understanding of SS disease.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f71ba076b6504199b9079bd9aa90105c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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