| Autor: |
Nada Mostafa Al-dardery, Omar Ahmed Abdelwahab, Mohamed Abouzid, Khaled Albakri, Ali Elkhadragy, Basant E. Katamesh, Rawan Hamamreh, Ahmed B. Mohd, Ahmed Abdelaziz, Abdulrhman Khaity |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-16 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2393 |
| DOI: |
10.1186/s12884-023-06100-8 |
| Popis: |
Abstract Background In this meta-analysis, we aimed to update the clinical evidence regarding the efficacy and safety of TXA in the prevention of PPH. Methods A literature search of PubMed, Scopus, Web of Science, Google Scholar, and Cochrane Library from inception until December 2022 was conducted. We included randomized controlled trials (RCTs) comparing TXA with a placebo among pregnant women. All relevant outcomes, such as total blood loss, the occurrence of nausea and/or vomiting, and changes in hemoglobin, were combined as odds ratios (OR) or mean differences (MD) in the meta-analysis models using STATA 17 MP. Results We included 59 RCTs (18,649 patients) in this meta-analysis. For cesarean birth, TXA was favored over the placebo in reducing total blood loss (MD= -2.11 mL, 95%CI [-3.09 to -1.14], P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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