Serum MMP-9, SP-D, and VEGF levels reflect the severity of connective tissue disease-associated interstitial lung diseases

Autor:	Chengna Lv, Qipan Zhang, Pan Tang, Lun Guo, Qunli Ding
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Connective tissue disease-associated interstitial lung disease Matrix metalloproteinase-9 Surfactant protein-D Vascular endothelial growth factor Diseases of the musculoskeletal system RC925-935 Immunologic diseases. Allergy RC581-607
Zdroj:	Advances in Rheumatology, Vol 62, Iss 1, Pp 1-9 (2022)
Druh dokumentu:	article
ISSN:	2523-3106
DOI:	10.1186/s42358-022-00269-w
Popis:	Key points Serum MMP-9, SP-D, and VEGF levels were increased in patients with CTD-ILD and they may have clinical value in screening and evaluating the severity of CTD-ILD. Serum SP-D and VEGF levels had a positive correlation with ILD severity as measured using semiquantitative HRCT scores. Serum MMP-9 levels were elevated in the UIP subgroup compared to the non-UIP subgroup. Therefore, further research is required to determine the role of serum MMP-9 levels in the preliminary determination of the ILD subtype. Serum MMP-9 levels had a negative correlation with DLco, and serum SP-D levels had a negative correlation with FVC.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ef70fca5a56a4719b9b9e49e76a7f465 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ