| Autor: |
Cartoni Claudia, Capuccini Silvia, Petrucci Paola, Ricci Giovanni, Di Bari Michele, Mandara Maria, Nonno Romolo, Pasquali Paolo, Macrì Agostino, Agrimi Umberto |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
BMC Veterinary Research, Vol 2, Iss 1, p 37 (2006) |
| Druh dokumentu: |
article |
| ISSN: |
1746-6148 |
| DOI: |
10.1186/1746-6148-2-37 |
| Popis: |
Abstract Background Prion diseases are characterised by a neurodegenerative pattern in which the function of immune system remains still elusive. In the present study, we evaluate if an exogenous treatment with Interleukin-12 (IL-12) and IL-18, able to activate microglia, is able to affect scrapie pathogenesis. Results Cytokines injected intracranially, induced a strong inflammatory response characterised by TNF-�� production and microglia activation. Two groups of mice were injected intracerebrally with high dose of ME7 strain of scrapie containing IL-12 and IL-18 or sterile saline. Cytokines-treated mice showed a more pronounced accumulation of PrPSc in brain tissues at 90 days post-inoculation and a shorter mean survival times than untreated mice. Conclusion We can conclude that intracerebral administration of IL-12 and IL-18 can modulate scrapie pathogenesis possibly through a microglia-mediated pattern. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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