An easy tool to predict survival in patients with bone metastatic lung cancer treated with palliative radiotherapy

Autor: Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki, Toshiyuki Kozuki
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Thoracic Cancer, Vol 14, Iss 19, Pp 1795-1801 (2023)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
97476331
DOI: 10.1111/1759-7714.14903
Popis: Abstract Background This study aimed to devise a simple assessment system for bone metastases (BMs) from lung cancer (LC). Methods A total of 368 LC patients with BMs who underwent radiotherapy (RT) were retrospectively reviewed. Prognostic factors were evaluated using multivariate analysis, and a scoring system based on regression coefficients was devised. Results The median follow‐up time for survival was 4.3 months, and the 0.5‐year overall survival (OS) rate was 44.7%. In the multivariate analysis, the significant prognostic factors were performance status (PS), metastases to internal organs, and post‐RT molecular‐targeting therapies (MTs) (tyrosine kinase inhibitors, and/or immune checkpoint inhibitors). A scoring system aggregating points assigned to each risk factor was created (2 points; non‐administration of post‐RT MTs, 1 point; PS ≥3 and metastases to internal organs). The median OSs were 25.0 months, 12.8 months, and 2.5 months in patients with a total score of 0 (n = 22), 1–2 (n = 124), and 3–4 (n = 221), respectively (p
Databáze: Directory of Open Access Journals
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