| Autor: |
Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-4889 |
| DOI: |
10.1038/s41419-020-03256-5 |
| Popis: |
Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), a cation channel characteristic of the prostate epithelium frequently overexpressed in advanced stage III/IV prostate cancers (PCa), sensitize therapy refractory models of PCa to radio, chemo or hormonal treatment. Overall, our study demonstrates that pharmacological-induced Ca2+ cytotoxicity is an actionable strategy to sensitize cancer cells to standard therapies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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