| Autor: |
Rajesh A. Rane, Mukesh Nandave, Suresh Nayak, Anushri Naik, Dhwani Shah, Wesam S. Alwan, Niteshkumar U. Sahu, Shital S. Naphade, Mahesh B. Palkar, Sivanandhan Karunanidhi, Neeta Thapliyal, Rajshekhar Karpoormath |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 10, Iss 4, Pp 458-464 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2014.06.004 |
| Popis: |
Hybrids of bromopyrrole alkaloids with aroyl hydrazone feature were synthesized and evaluated for their anti-inflammatory activity using the carrageenan induced rat paw edema method. All the tested hybrids showed good anti-inflammatory activity with 64.78–86.03% inhibition of edema. Most active hybrids 4b and 4f were further investigated for antihistaminic H1 [4b −8.09 μg/mL (18.5 μM); 4f −9.26 μg/mL (24.05 μM)] and anti-serotonergic 5-HT3 [4b −7.01 μg/mL (16.04 μM); 4f −9.64 μg/mL (25.04 μM)] activities. Molecule 4f with anti-inflammatory, anti-histaminic and anti-serotonergic activities emerges as a potential anti-inflammatory lead form in this study. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
