Protein–protein and protein-nucleic acid binding residues important for common and rare sequence variants in human

Autor:	Jiajun Qiu, Dmitrii Nechaev, Burkhard Rost
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Genome sequence analysis Single amino acid variants (SAVs) Macro-molecular binding residues DNA-binding RNA-binding Protein–protein binding Computer applications to medicine. Medical informatics R858-859.7 Biology (General) QH301-705.5
Zdroj:	BMC Bioinformatics, Vol 21, Iss 1, Pp 1-17 (2020)
Druh dokumentu:	article
ISSN:	1471-2105
DOI:	10.1186/s12859-020-03759-0
Popis:	Abstract Background Any two unrelated people differ by about 20,000 missense mutations (also referred to as SAVs: Single Amino acid Variants or missense SNV). Many SAVs have been predicted to strongly affect molecular protein function. Common SAVs (> 5% of population) were predicted to have, on average, more effect on molecular protein function than rare SAVs (
Databáze:	Directory of Open Access Journals
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