Association of Elevated Blood Pressure Levels with Outcomes in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A Systematic Review and Meta-Analysis
| Autor: | Konark Malhotra, Niaz Ahmed, Angeliki Filippatou, Aristeidis H. Katsanos, Nitin Goyal, Konstantinos Tsioufis, Efstathios Manios, Maria Pikilidou, Peter D. Schellinger, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Stroke, Vol 21, Iss 1, Pp 78-90 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2287-6391 2287-6405 |
| DOI: | 10.5853/jos.2018.02369 |
| Popis: | Background and Purpose Although arbitrary blood pressure (BP) thresholds exist for acute ischemic stroke (AIS) patients eligible for intravenous thrombolysis (IVT), current international recommendations lack clarity on the impact of mean pre- and post-IVT BP levels on clinical outcomes. Methods Eligible studies involving IVT-treated AIS patients were identified that reported the association of mean systolic BP (SBP) or diastolic BP levels before and after IVT with the following outcomes: 3-month favorable functional outcome (modified Rankin Scale [mRS] scores of 0–1) and 3-month functional independence (mRS scores of 0–2), 3-month mortality and symptomatic intracranial hemorrhage (sICH). Unadjusted analyses of standardized mean differences and adjusted analyses of studies reporting odds ratios (ORadj) per 10 mm Hg BP increment were performed using random-effects models. Results We identified 26 studies comprising 56,513 patients. Higher pre- (P=0.02) and posttreatment (P=0.006) SBP levels were observed in patients with sICH. Patients with 3-month functional independence had lower post-treatment (P |
| Databáze: | Directory of Open Access Journals |
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