| Autor: |
Elham Metawae, Nader Abd-Alhamid, Salama Abd-Allatif, Nagwa Abd-Elghaffar, Eman El-Ghoroury, Amany Abd-Elrahman, Ingy Ashmawy, Zahraa Aboafya |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Al-Azhar Assiut Medical Journal, Vol 16, Iss 1, Pp 81-86 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1687-1693 |
| DOI: |
10.4103/AZMJ.AZMJ_47_18 |
| Popis: |
Background Breast cancer (BC) is the most common cancer among Egyptian women, and its early detection is accompanied with decreased mortality rates. MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression and affect cancer development. The expression level of miRNA-155 is up-regulated in BC and correlates with its invasive properties, offering a great potential as a noninvasive biomarker for BC screening. Objective The aim of this study is to evaluate the role of miRNA-155 as an early diagnostic serum-based biomarker of BC. Patients and methods This study was conducted on 30 patients newly diagnosed with BC and associated 20 healthy women as a control group. Serum level of miRNA-155 was measured for all studied cases using real-time quantitative PCR technique. Results MiRNA-155 expression was up-regulated in serum of patients with BC compared with control group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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