Pain Relief and Kaempferol: Activation of Transient Receptors Potential Vanilloid Type 1 in Male Rats
| Autor: | Mohammad Zarei, Zohre Izadi Dastenaei, Sajjad Jabbari |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | پژوهان, Vol 18, Iss 2, Pp 81-89 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1029-7863 2423-6276 |
| Popis: | Background and Objective: Pain an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Kaempferol is one of the most important herbal active constituent with antinociceptive effects. The aim of this study was to evaluate the effects of intracerebroventricular injection of kaempferol and its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) on pain in male rats. Materials and Methods: In this experimental study, sixty male rats (200-250 g) were divided to the following groups: control (saline), Dimethyl sulfoxide (DMSO), morphine, kaempferol at dosages of 0.5, 1, and 1.5 mg/rat, capsaicin, capsazepine, capsaicin plus kaempferol (1.5 mg/rat), capsazepine plus kaempferol (1.5 mg/rat). After cannula implantation in cerebroventricular area, the rats received target components and then evaluated by pain assessment tests (abdominal writhing, tail-flick, and formalin tests). Data were analyzed by one-way ANOVA followed by Tukey’s post-test and P |
| Databáze: | Directory of Open Access Journals |
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