REPEAT MYOCARDIAL REVASCULARIZATION IN LONG-TERM PERIOD AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND STABLE ANGINA PECTORIS

Autor: V K Zafiraki, E D Kosmacheva
Jazyk: English<br />Russian
Rok vydání: 2017
Předmět:
Zdroj: Клиническая практика, Vol 8, Iss 3, Pp 42-47 (2017)
Druh dokumentu: article
ISSN: 2220-3095
2618-8627
DOI: 10.17816/clinpract8342-47
Popis: Objective. To assess the effect of some characteristics of chronic obstructive pulmonary disease (COPD) in patients after elective percutaneous coronary intervention (PCI) on repeat myocardial revascularization frequency in long-term period (up to 3 year).Materials and methods. 135 patients with COPD, who suffered stable ischemic heart disease and were underwent PCI, were included in prospective observational study. Follow-up duration was up to3 year. Evaluation included comparing the frequency of elective repeat revascularization in regards to frequent COPD exacerbations, COPD severity, lung function and C-reactive protein (CRP) plasm level. Comparing Kaplan-Mayer curves and Cox regression analysis were also applied.Results. Elective repeat myocardial revascularization frequency was 23% and 2,1 times higher among the patients who had frequent COPD exacerbations history (95% CI 1,1-3,9). The difference between Kaplan-Mayers curves was also detected as statistically significant (p=0,016). None of the pulmonary function characteristics had relations with elective repeat revascularization frequency increase. Frequent COPD exacerbations history and CRP plasma level were included in Cox regression model as non-cardiovascular variables (p=0,05 and 0,08 respectively).Conclusions. Frequent COPD exacerbations history and increased CRP plasma level are indepen- dent non-cardiovascular variables related to increased risk of elective repeat myocardial revasculariza- tion. None of the pulmonary function characteristics had relations with elective repeat revasculariza- tion frequency increase.
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