Disease activity correlates and functionality in patients with rheumatoid arthritis – real-world experience from a South Asian country
| Autor: | Noreen Nasir, Hafsa Majid, Ayesha Habib Khan, Safia Awan, Mohammed Mehmood Riaz |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Rheumatology, Vol 60, Iss 3, Pp 183-191 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0034-6233 2084-9834 |
| DOI: | 10.5114/reum.2022.117838 |
| Popis: | Introduction There is a lack of data assessing disease activity in patients with rheumatoid arthritis from Pakistan. We sought to determine the correlation between Disease Activity Score 28 (DAS28) and disease activity parameters and the modified Health Assessment Questionnaire (mHAQ). Secondarily, we evaluated the concordance of acute phase reactants with disease activity. Material and methods We prospectively studied 132 patients with rheumatoid arthritis (RA) as per the 2010 American College of Rheumatology/European League Against Rheumatism criteria, not in clinical remission. Based on the DAS28 score, the patients were divided into low, moderate, and high activity groups. The patients were also categorized according to the elevation of acute phase reactants to determine concordance and discordance with DAS28–ESR and DAS28–CRP. Descriptive statistics and Pearson’s correlation were computed. Results Complete demographics was available for 132 participants. The mean age was 46.2 ±12.8 years; there were 85.6% (n = 113) females. The mean disease duration was 5.7 ±6.4 years. The (Rephrase as mean ±SD) DAS28 and mHAQ scores were 3.4 ±1.8 and 0.77 ±0.68, respectively. A significant correlation was observed between DAS28 and tender and swollen joint count (r = 0.64; p |
| Databáze: | Directory of Open Access Journals |
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