| Autor: |
Mohammad Shaharyar, Avijit Mazumder, Salahuddin, Ruchika Garg, Rishabh D Pandey |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 9, Iss S1, Pp S342-S347 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2011.04.013 |
| Popis: |
In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and some compounds containing oxadiazole bearing benzimidazole were synthesized by using various aromatic aldehyde, cyanogens bromide and carbon disulfide/potassium hydroxide. These were elucidated by IR, NMR and elemental analysis and their in vivo anticonvulsant screening was performed using MES and scPTZ. Two compounds 7g and j were found to be potent in both the screens and their protective index was found to be better than standard drugs used. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
