Immunity Enhancement Activity and Mechanism of Ganoderma lucidum-Panax quiquefolium L.-Cordyceps sinensis compound Based on Network Pharmacology

Autor: Wanxing WU, Zhihui DUAN, Lixuan XUE, Xiaodong WANG
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Shipin gongye ke-ji, Vol 44, Iss 8, Pp 392-404 (2023)
Druh dokumentu: article
ISSN: 1002-0306
DOI: 10.13386/j.issn1002-0306.2022060329
Popis: In this study, the immunity enhancement activity of Ganoderma lucidum-Cordyceps sinensis-Panax quiquefolium L. compound (here in after referred to as "compound") was systematically evaluated, and its mechanism was explored by network pharmacology. The NK cell activity, delayed allergic reaction, spleen lymphocyte proliferation and monocyte-macrophage phagocytosis of compound were investigated to evaluate its immunity enhancement activity. The results in vivo and in vitro indicated the low, medium and high dose groups (0.4, 0.8, 2.4 g/kg) of compound could significantly increase NK cell activity (P
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