The landscape of gene co-expression modules correlating with prognostic genetic abnormalities in AML

Autor:	Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Acute myeloid leukemia Weighted co-expression network analysis Prognostic signature Medicine
Zdroj:	Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Druh dokumentu:	article
ISSN:	1479-5876
DOI:	10.1186/s12967-021-02914-2
Popis:	Abstract Background The heterogenous cytogenetic and molecular variations were harbored by AML patients, some of which are related with AML pathogenesis and clinical outcomes. We aimed to uncover the intrinsic expression profiles correlating with prognostic genetic abnormalities by WGCNA. Methods We downloaded the clinical and expression dataset from BeatAML, TCGA and GEO database. Using R (version 4.0.2) and ‘WGCNA’ package, the co-expression modules correlating with the ELN2017 prognostic markers were identified (R2 ≥ 0.4, p
Databáze:	Directory of Open Access Journals
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