Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients

Autor:	Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz, Asta Försti
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	GWAS Chemotherapy Neuropathy Multiple myeloma Adverse drug reaction Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-018-4728-4
Popis:	Abstract Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Methods Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values
Databáze:	Directory of Open Access Journals
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