| Autor: |
Camila G. Jange, Carl R. Wassgren, Kingsly Ambrose |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Powders, Vol 2, Iss 1, Pp 99-123 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2674-0516 |
| DOI: |
10.3390/powders2010008 |
| Popis: |
The internal microstructure of a tablet, such as pore geometry and pore volume, impacts the tablet’s disintegration kinetics. Ideally, one could design the microstructure to control dissolution onset and therapeutical performance of immediate-release formulas; however, manufacturing tablets with a desired microstructure can be challenging due to the interplay between formulation and process parameters. Direct quantification of tablet microstructure can provide a framework for optimizing composition and process parameters based on a Quality-by-Design approach. This article reviews the importance of tablet microstructure design and liquid transport kinetics to help optimize the release and dissolution profiles of immediate-release products. Additionally, the formulation and process parameters influencing the tablet microstructure and liquid transport kinetics are discussed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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