The diagnostic challenges of differentiating metastatic extramammary Paget disease and prostatic adenocarcinoma: A case report and review of the literature

Autor: Gregory Palmateer, Edouard H. Nicaise, Jatin Gandhi, Taylor Goodstein, Michelle Sheng, Kenneth Ogan, Omer Kucuk, Melinda Yushak, Martin G. Sanda, Keith A. Delman, Viraj Master
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Urology Case Reports, Vol 57, Iss , Pp 102875- (2024)
Druh dokumentu: article
ISSN: 2214-4420
DOI: 10.1016/j.eucr.2024.102875
Popis: Extramammary Paget disease (EMPD) is a rare dermatologic malignancy with a high rate of recurrence and increased risk for developing secondary malignancies. We present a 74-year-old male with previously resected primary EMPD who presented with widespread PSMA-avid lesions without prostatic uptake, an elevated PSA >100, and a negative prostate biopsy. Based on this and immunohistological staining, recurrent EMPD was suspected. However, after additional staining and reexamining their clinical presentation, metastatic prostate cancer without a detected primary lesion is more probable. This case highlights the diagnostic challenge variable expression of shared biomarkers found in EMPD and prostate cancer present to clinicians.
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