Patients with advanced cancer were treated with immune checkpoint inhibitors and injected with COVID-19 vaccine to improve their prognosis without increasing pancreatic related adverse events

Autor:	Min Li, Lingling Liao, Wei Huang, Hui Feng, Wanqing Wang, Nana Huang, Zhiyan Zhao, Yu Shi, Jinglu Ye, Kangsheng Gu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Immune checkpoint inhibitors (ICIs) immune-related pancreatic toxicity pancreatic enzymes COVID-19 vaccine Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950
Zdroj:	Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	21645515 2164-554X 2164-5515
DOI:	10.1080/21645515.2024.2358575
Popis:	To investigate immune checkpoint inhibitors (ICIs) induced pancreatic injury (ICIPI), the prognostic effect of COVID-19 vaccine on cancer patients, and whether COVID-19 vaccine increases the incidence of ICIPI. We conducted a retrospective study of 256 stage IV cancer patients treated with ICIs at The First Affiliated Hospital of Anhui Medical University from January 2020 to November 2022. Data collected included pancreatic enzyme levels, treatment outcomes, and vaccination status. Statistical significance was determined using the χ2 test and Kaplan-Meier method (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f636f6a042a14e9baf122765f32688bc Zobrazit plný text záznamu View record in DOAJ