Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
| Autor: | Jiwon Ryu, Eunji Baek, Hyung-Eun Son, Ji-Young Ryu, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Dong-Wan Chae, Seong Pyo Kim, Su Hwan Kim, Jong Hyun Jhee, Tae Ik Chang, Bum Soon Choi, Ho Jun Chin |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Kidney Research and Clinical Practice, Vol 42, Iss 1, Pp 98-108 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2211-9132 2211-9140 |
| DOI: | 10.23876/j.krcp.22.042 |
| Popis: | Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. Methods We extracted primary GN data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as C3 staining two grades greater than C1q, C4, and immunoglobulin via immunofluorescence analysis. To overcome a large difference in the number of patients between the C3D-GN and C3ND-GN groups (31 vs. 9,689), permutation testing was used for analysis. Results The C3D-GN group exhibited higher serum creatinine (p ≤ 0.001), a greater prevalence of estimated glomerular filtration rate of |
| Databáze: | Directory of Open Access Journals |
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