Rhamnazin inhibits proliferation and induces apoptosis of human jurkat leukemia cells in vitro

Autor:	А. А. Philchenkov, М. P. Zavelevych
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	acute lymphoblastic leukemia apoptosis caspases cell cycle flavonoids flow cytometry Biochemistry QD415-436 Medicine Biology (General) QH301-705.5
Zdroj:	The Ukrainian Biochemical Journal, Vol 87, Iss 6, Pp 122-128 (2015)
Druh dokumentu:	article
ISSN:	2409-4943 2413-5003
DOI:	10.15407/ubj87.06.122
Popis:	Antiproliferative and apoptogenic effects of rhamnazin, a dimethoxylated derivative of quercetin, were studied in human acute lymphoblastic leukemia Jurkat cells. The cytotoxicity and apoptogenic activity of rhamnazin in vitro are inferior to that of quercetin. The apoptogenic activity of rhamnazin is realized via mitochondrial pathway and associated with activation of caspase-9 and -3. The additive apoptogenic effect of rhamnazin and suboptimal doses of etoposide, a DNA topoisomerase II inhibitor, is demonstrated. Therefore, methylation of quercetin modifies its biological effects considerably.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f6140ce5734746bea405a3247856314d Zobrazit plný text záznamu View record in DOAJ