Characterization of a Plasmodium falciparum mutant that has deleted the majority of the gametocyte-specific Pf11-1 locus

Autor:	Artur Scherf, Carolyn Petersen, Richard Carter, Pietro Alano, Rick Nelson, Masamichi Aikawa, Denise Mattei, Luiz Pereira da Silva, James Leech
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	chromosome breakage and healing gametocyte specific antigen telomere HRPI HRP II deletions Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 91-94 (1992)
Druh dokumentu:	article
ISSN:	0074-0276 1678-8060
DOI:	10.1590/S0074-02761992000700012
Popis:	We identified a gametocyte-specific protein of Plasmodium falciparum called Pf11-1 and provide experimental evidence that this molecule is involved in the emergence of gametes of the infected erythrocyte (gametogenesis). A mutant parasite clone, which has deleted over 90% of the PF11-1 gene locus, was an important control to establish the gametocyte-specific expression of the Pf11-1. Molecular analysis of the Pf11-1 deletion indicates that it is presumably due a chromosome breakage with subsequent "healing" by the addition of telomeric heptanucleotides. Moreover, similar DNA rearrangements are observed in most of the laboratory isolates during asexual propagation in vitro.
Databáze:	Directory of Open Access Journals
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