Comparison of irradiated and non-irradiated acellular dermal matrices in breast reconstruction under radiotherapy
| Autor: | Soo Jin Woo, Jeong Hyun Ha, Ung Sik Jin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Archives of Plastic Surgery, Vol 48, Iss 01, Pp 33-43 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2234-6163 2234-6171 |
| DOI: | 10.5999/aps.2020.01522 |
| Popis: | Background Acellular dermal matrices (ADMs) have become an essential material for implant-based breast reconstruction. No previous studies have evaluated the effects of sterility of ADM under conditions of radiation. This study compared sterile (irradiated) and aseptic (non-irradiated) ADMs to determine which would better endure radiotherapy. Methods Eighteen male Balb/C mice were assigned to the control group with no irradiation (group 1) or one of two other groups with a radiation intensity of 10 Gy (group 2) or 20 Gy (group 3). Both sterile and aseptic ADMs were inserted into the back of each mouse. The residual volume of the ADM (measured using three-dimensional photography), cell incorporation, α-smooth muscle actin expression, and connective tissue growth factor expression were evaluated. The thickness and CD3 expression of the skin were measured 4 and 8 weeks after radiation. Results In groups 2 and 3, irradiated ADMs had a significantly larger residual volume than the non-irradiated ADMs after 8 weeks (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|