Simvastatin reduces chronic kidney disease and renal failure risk in type 2 diabetes patients: post hoc ACCORD trial analysis

Autor: Jiaxi Pu, Ming Gao, Pan Yu, Jiaqi Tian, Junxia Yan, Qiongjing Yuan, Lijian Tao, Zhangzhe Peng
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-7 (2024)
Druh dokumentu: article
ISSN: 1758-5996
DOI: 10.1186/s13098-024-01514-6
Popis: Abstract Objective Type 2 diabetes mellitus (T2DM) poses a substantial global health concern. Statins are widely used among T2DM patients for managing dyslipidemia, preventing cardiovascular disease (CVD), and offering renal protection. However, the extent to which their renal protective effects contribute to reducing the incidence of severe renal complications, including chronic kidney disease (CKD) and renal failure, is not well-defined. Methods This investigation scrutinizes the impact of simvastatin versus placebo on renal outcomes among T2DM patients utilizing data from the ACCORD trial. It encompasses incidence rate comparisons, Kaplan-Meier estimates, Cox proportional hazards models, and mediation analyses. Results The study consisted of 3,619 individuals diagnosed with T2DM, among which 2,753 were treated routinely with simvastatin, while 866 did not receive any statin therapy. After adjusting for baseline characteristics and time-dependent covariates, simvastatin treatment was associated with a 71% reduction in the risk of CKD (HR 0.29, 95% CI 0.27–0.31, p
Databáze: Directory of Open Access Journals
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