Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis

Autor: Christopher C. Huntley, Ketan Patel, Shahnoor-E-Salam Bil Bushra, Farah Mobeen, Michael N. Armitage, Anita Pye, Chloe B. Knight, Alyaa Mostafa, Marie Kershaw, Aishah Z. Mughal, Emily McKemey, Alice M. Turner, P. Sherwood Burge, Gareth I. Walters
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: ERJ Open Research, Vol 8, Iss 2 (2022)
Druh dokumentu: article
ISSN: 2312-0541
23120541
DOI: 10.1183/23120541.00056-2022
Popis: Background The COVID-19 pandemic follows severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus epidemics. Some survivors of COVID-19 infection experience persistent respiratory symptoms, yet their cause and natural history remain unclear. Follow-up after SARS and MERS may provide a model for predicting the long-term pulmonary consequences of COVID-19. Methods This systematic review and meta-analysis aims to describe and compare the longitudinal pulmonary function test (PFT) and computed tomography (CT) features of patients recovering from SARS, MERS and COVID-19. Meta-analysis of PFT parameters (DerSimonian and Laird random-effects model) and proportion of CT features (Freeman-Tukey transformation random-effects model) were performed. Findings Persistent reduction in the diffusing capacity for carbon monoxide following SARS and COVID-19 infection is seen at 6 months follow-up, and 12 months after MERS. Other PFT parameters recover in this time. 6 months after SARS and COVID-19, ground-glass opacity, linear opacities and reticulation persist in over 30% of patients; honeycombing and traction dilatation are reported less often. Severe/critical COVID-19 infection leads to greater CT and PFT abnormality compared to mild/moderate infection. Interpretation Persistent diffusion defects suggestive of parenchymal lung injury occur after SARS, MERS and COVID-19 infection, but improve over time. After COVID-19 infection, CT features are suggestive of persistent parenchymal lung injury, in keeping with a post-COVID-19 interstitial lung syndrome. It is yet to be determined if this is a regressive or progressive disease.
Databáze: Directory of Open Access Journals
Externí odkaz: