| Autor: |
Marion I. van den Heuvel, Elise Turk, Janessa H. Manning, Jasmine Hect, Edgar Hernandez-Andrade, Sonia S. Hassan, Roberto Romero, Martijn P. van den Heuvel, Moriah E. Thomason |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Developmental Cognitive Neuroscience, Vol 30, Iss , Pp 108-115 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1878-9293 |
| DOI: |
10.1016/j.dcn.2018.02.001 |
| Popis: |
Advances in neuroimaging and network analyses have lead to discovery of highly connected regions, or hubs, in the connectional architecture of the human brain. Whether these hubs emerge in utero, has yet to be examined. The current study addresses this question and aims to determine the location of neural hubs in human fetuses. Fetal resting-state fMRI data (N = 105) was used to construct connectivity matrices for 197 discrete brain regions. We discovered that within the connectional functional organization of the human fetal brain key hubs are emerging. Consistent with prior reports in infants, visual and motor regions were identified as emerging hub areas, specifically in cerebellar areas. We also found evidence for network hubs in association cortex, including areas remarkably close to the adult fusiform facial and Wernicke areas. Functional significance of hub structure was confirmed by computationally deleting hub versus random nodes and observing that global efficiency decreased significantly more when hubs were removed (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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