603 Covalent attachment of a TLR7/8 agonist to tumor-targeting antibodies drives potent anti-tumor efficacy by synergistically activating FcgR- and TLR- signaling and enables safe systemic administration

Autor: David Jackson, Shelley Ackerman, David Dornan, Michael Alonso, Felix Hartmann, Cecelia Pearson, Joseph Gonzalez, Po Yi Ho, Samuel Kimmey, Andrew Luo, Benjamin Ackerman, Arthur Lee, Richard Laura, Jason Paik, Karla Henning, Steven Chapin, Bruce Devens, Sean Bendall, Edgar Engleman
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Druh dokumentu: article
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-SITC2020.0603
Databáze: Directory of Open Access Journals