| Autor: |
Teresa A. Colvin, Pankit Vachhani, Sheila Sait, Vishala Neppalli, Eunice S. Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 10, Iss , Pp 16-19 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2018.07.002 |
| Popis: |
A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-expression of chimeric BCL/ABL and PML/RARα translocations by karyotyping, fluorescence in situ hybridization, and quantitative real-time polymerase chain reaction. Promyelocytic blast crisis of CML is a rare event with historically poor outcomes. Treatment of our patient with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) resulted in complete morphologic remission. We review here the relevant literature of promyelocytic blast crisis and highlight the potential of ATRA/ATO as first line management. Keywords: ATRA, ATO, CML, Promyelocytic, Blast crisis |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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