| Autor: |
V. V. Golotiuk, M. M. Bagriy |
| Jazyk: |
Russian<br />Ukrainian |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Морфологія, Vol 10, Iss 3, Pp 99-103 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1997-9665 |
| DOI: |
10.26641/1997-9665.2016.3.99-103 |
| Popis: |
Background. Considering the importance of nitric oxide in the malignant growth pathogenesis, researchers are actively exploring properties of nitric oxide synthesis biological systems in colorectal cancer tumors. However, literature data according the characteristics of iNOS expression in colorectal cancer and its prognostic and predictive value is ambiguous. Objective: to define the features of iNOS expression in intact colon and rectal cancer tissues before treatment and after the course of neoadjuvant chemoradiotherapy, including the background of the drug precursor of nitric oxide. Methods. iNOS expression indexes were determined by immunohistochemistry in the biopsy and surgical material in 24 patients with adenocarcinoma of the rectum stage II-III before and after neoadjuvant chemoradiotherapy. Results. It was revealed 4.5 times higher levels of iNOS expression in the rectal cancer tumor compared with intact mucosa. Rectal cancer iNOS is expressed in tumor parenchyma cells and in tumor stroma, the level of immunosignal in stroma is 24% higher compared with parenchyma. Positive correlation (r= 0.74; р |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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