| Autor: |
Anushia Ashokan, Josh Hanson, Ne Myo Aung, Mar Mar Kyi, Steven L. Taylor, Jocelyn M. Choo, Erin Flynn, Fredrick Mobegi, Morgyn S. Warner, Steve L. Wesselingh, Mark A. Boyd, Geraint B. Rogers |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Antimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-10 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2047-2994 |
| DOI: |
10.1186/s13756-021-00915-w |
| Popis: |
Abstract Background Antimicrobial resistance (AMR) represents a profound global health threat. Reducing AMR spread requires the identification of transmission pathways. The extent to which hospital wards represent a venue for substantial AMR transmission in low- and middle-income countries settings is poorly understood. Methods Rectal swabs were obtained from adult male inpatients in a “Nightingale” model general medicine ward in Yangon, Myanmar. Resistome characteristics were characterised by metagenomic sequencing. AMR gene carriage was related to inter-patient distance (representing inter-patient interaction) using distance-based linear models. Clinical predictors of AMR patterns were identified through univariate and multivariate regression. Results Resistome similarity showed a weak but significant positive correlation with inter-patient distance (r = 0.12, p = 0.04). Nineteen AMR determinants contributed significantly to this relationship, including those encoding β-lactamase activity (OXA-1, NDM-7; adjusted p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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